Daily Circulation

Serving size 1 vegetable capsule • Servings per container 10

*Nutritional Reference Value; - NRV not established

Delphinol® is a registered trademark of Anklam Extrakt GmbH (Germany) and Maqui New Life SA (Chile). Pycnogenol® is a registered trademark of Horphag Research.

Ingredients

Standardized maqui berry (Aristotelia chilensis) extract, hydroxypropyl methylcellulose (capsule shell), standardized extract of ginger root (Zingiber officinale), standardized French maritime pine bark (Pinus pinaster) extract, bulking agent: microcrystalline cellulose.

Recommended Intake

For adults, take 1 vegetable capsule daily with water during a meal.

Warning

• Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.
• Do not exceed the stated recommended daily dose.
• The product should be stored out of reach of young children.
• Do not use if you are pregnant or while breastfeeding.
• If you have any medical condition, consult a healthcare practitioner before taking any food supplement.
• Store in a cool and dry place.

Maqui Berry Extract (Delphinol®)

Aristotelia chilensis commonly known as maqui berry is a native South American evergreen shrub that grows wild in the pristine Patagonia region mainly in Chile and Argentina. Since ancient times, the indigenous Mapuche culture traditionally consumed it and used it for its great healing powers. Today, maqui is considered a superfruit for its special properties and natural nutrients, including alkaloids, cinnamic and benzoic acid derivatives, mineral elements and polyphenols. The polyphenols and the anthocyanins present in maqui berries are water-soluble plant pigments that have a strong antioxidant activity, of which the delphinidins are the most potent antioxidative group. Indeed, Delphinol® is the richest natural source of anthocyanins and delphinidins actives.

French Maritime Pine Bark Extract (Pycnogenol®)

French maritime pine bark is an extract from the outer pine bark of Pinus pinaster a mono-species growing in Southwest France in Les Landes de Gascogne, also France's largest forest. The use of pine bark was first documented back in 1535, during Jacques Cartier's expedition to Canada the fleet lay stuck on a frozen a river for several months, lacking fresh supplies. The members of the crew who had suffered from severe scurvy were treated with a tea made of pine bark and needles several times a day, recommended by the Iroquois Indians. It was later discovered that besides some vitamin C content, pine bark contains bioflavonoids in abundance.

Over 40 years of research have been dedicated to establishing the safety, efficacy and quality of Pycnogenol®.

Pycnogenol®, as a standardized extract of pine bark, contains a combination of procyanidins, bioflavonoids (catechin, taxifolin) and various organic acids in naturally defined constant proportions, which offer health benefits including in circulatory health.

HOW DOES DAILY CIRCULATION SUPPORT GOOD BLOOD CIRCULATION AND ASSISTS MICROCIRCULATION?

The support on well-being provided by Daily Circulation (Zinopin®) significantly benefits from the combined antioxidant potency delivered by all active constituents. Maqui berry, with its high content of phenolics with considerable antioxidant capacity, may protect LDL from oxidation and endothelial cells (innermost layer of the arteries) from intracellular oxidative stress.¹ A group of researchers showed that after four weeks intake of Delphinol®, a significant reduction of oxidized LDL (low density lipoprotein) cholesterol and F2-isoprostane is observed in human moderately overweight volunteer smokers, compared to placebo.²

Pycnogenol® French maritime pine bark extract is known as a strong antioxidant demonstrating the potent neutralisation of free radicals in humans, beneficial activities particularly for the cardiovascular system. In one investigation, Pycnogenol® intake significantly increased antioxidant capacity of plasma, as determined by ORAC, and shows favorable effects on human lipid profile.³

These results were confirmed by a twelve-week clinical trial including young healthy volunteers supplemented with Pycnogenol®, which indicate an increased endothelial nitric oxide synthesis, present in endothelial cells, that act on blood platelets to decrease their tendency to form aggregates.⁴ Thus, Pycnogenol® was shown to improve vascular function by improvement of endothelial function, enabling vessels to naturally dilate in support of a smoother blood flow.

Ginger root active constituents have been documented for their pharmacological activities including anti-platelet aggregation and vasorelaxing effects.⁵ Although In vitro studies demonstrate ginger compounds inhibit platelet aggregation, a systematic review of several existing human studies on the potential effect of ginger compared to placebo or baseline, reported inconsistent results.⁶ Furthermore, a meta-analysis on the effects of ginger reveal a significant lipid-lowering effect, in particular with a favorable effect on total cholesterol, LDL (low density lipoprotein) cholesterol and triglycerides.⁷

References

¹ Romanucci V., et al. (2016). Bioactive compounds of Aristotelia chilensis Stuntz and their pharmacological effects. Curr. Pharm. Biotechnol., 17(6), 513-523.
² Davinelli S., et al. (2015). A randomized clinical trial evaluating the efficacy of anthocyanin-maqui berry extract Delphinol® on oxidative stress biomarkers. J Am. Coll. Nutr., 34(SI):28-33.
³ Devaraj S., et al. (2002). Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids, 37(10):931-934.
⁴ Nishioka K., et al. (2007). Pycnogenol® French maritime pine bark extract, augments endothelium-dependent vasodilation in humans. Hypertension Res., 30(9):775-780.
⁵ Liao Y.R., et al. (2012). Anti-platelet aggregation and vasorelaxing effects of the constituents of the rhizomes of Zingiber officinale. Molecules, 17, 8928-8937.
⁶ Marx W., et al. (2015). The effect of ginger (Zingiber officinale) on platelet aggregation: A systematic literature review. LOS One, 10(10), e0141119.
⁷ Fakhri Z., et al. (2018). The effects of ginger supplementation on lipid profile: A meta-analysis of randomized clinical trials. J. Herb. Med., 3(3), 120-131.